What question did this study set out to answer?

To compare the therapeutic efficacy, overall tolerability, and specific effects on sexual dysfunction of moclobemide versus doxepin in patients with major depression.

January 1, 1993International Clinical Psychopharmacology

A comparison study of moclobemide and doxepin in major depression with special reference to effects on sexual dysfunction

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Authors

MPMichael PhilippDeutsches Jugendinstitut RKR. KohnenGeorg Simon Ohm University of Applied Sciences Nuremberg OBOtto BenkertUniversity of Applied Sciences Mainz

Discussion

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Implication

Double-blind trial reveals moclobemide matches doxepin efficacy while improving sexual function in major depression, indicating favorable tolerability over anticholinergic antidepressants.

Key Points

To compare the therapeutic efficacy, overall tolerability, and specific effects on sexual dysfunction of moclobemide versus doxepin in patients with major depression.
Conducted a double-blind, parallel-group comparison trial in 237 patients diagnosed with major depression.
Assessed adverse events, sedation, and specific sexual dysfunction symptoms (libido, erection, ejaculation, and orgasm) using the UKU side-effect rating scale.
Moclobemide demonstrated equal antidepressant efficacy to doxepin while causing less sedation and fewer anticholinergic adverse events on the UKU scale.
Moclobemide treatment was associated with higher rates of increased sexual desire and greater symptom improvement in reduced libido, impaired erection, ejaculation, and orgasm compared to doxepin.

Cite This Study

Philipp et al. (1993) studied this question.

synapsesocial.com/papers/6a899717b4e829b19bd454bf https://doi.org/10.1097/00004850-199300730-00005

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Implication

Double-blind trial reveals moclobemide matches doxepin efficacy while improving sexual function in major depression, indicating favorable tolerability over anticholinergic antidepressants.

A comparison study of moclobemide and doxepin in major depression with special reference to effects on sexual dysfunction

Discussion

Member takes

Implication

Key Points

Cite This Study

A comparison study of moclobemide and doxepin in major depression with special reference to effects on sexual dysfunction

Discussion

Member takes

Implication

Key Points

Cite This Study

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