Why the study?
Does flunarizine or ryanodine prevent the induction of acquired Torsades de Pointes arrhythmias in a canine model?
Does flunarizine or ryanodine prevent the induction of acquired Torsades de Pointes arrhythmias in a canine model?
Blockade of the sarcoplasmic reticulum Ca2+ release channel or reduction of intracellular Ca2+ overload prevents acquired Torsades de Pointes in a canine model, highlighting the role of Ca2+ overload in EAD-dependent arrhythmias.
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Hypothesis-generating for Ca2+ modulation in acquired TdP; leaves open human translation.
Verduyn et al. (1995) studied this question.
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