Key result
IV ryanodine prolongs canine LV contraction and relaxation and depresses velocity while maintaining force.
Why the study?
Does ryanodine alter left ventricular function indexes in intact dogs?
Does ryanodine alter left ventricular function indexes in intact dogs?
p-value: p=<0.001
Low-dose ryanodine in intact dogs causes generalized slowing of LV mechanical events and dissociates velocity-based from force-based measures of LV function.
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Alerts researchers to dissociation of velocity- versus force-based LV indices; leaves open translation to human systolic assessment.
Prabhu et al. (1997) studied this question. Ryanodine vs. Baseline (before administration) was evaluated on Left ventricular contraction and relaxation (p=<0.001). Intravenous ryanodine in intact dogs prolonged left ventricular contraction and relaxation (P<0.001) and depressed velocity-based measures while maintaining force-based measures.
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