Population
Six anesthetized dogs
Comparison
Intra-aortic balloon inflation to increase peak… vs Control conditions (no asynchrony, no ryanodine)
Design
Preclinical
Authors
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Should not alter clinical LV relaxation management; extends canine mechanistic data but leaves open human translation.
In a canine model, asynchrony and ryanodine modulate the extent of load-dependent relaxation in the intact left ventricle.
Wilbur Y.W. Lew (1995) studied this question.
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