Population
7 chloralose anaesthetised open chest dogs instrumented with a left ventricular pressure gauge and…
Comparison
Acute increase in left ventricular afterload by… vs Baseline/control state prior to aortic clamping
Design
Preclinical
Authors
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May link acute afterload to relaxation prolongation via asynchrony in this model; leaves open translation to human diastolic function.
Acute augmentation of left ventricular afterload increases left ventricular asynchrony, which may contribute to the prolongation of left ventricular isovolumetric relaxation.
Schäfer et al. (1992) studied this question.
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