Key result
Cardiac magnetic resonance imaging of female db/db mice demonstrated significant increases in left ventricular mass and wall thickness by 9 weeks, and a significant decrease in LVEF by 22 weeks.
Population
Female db/db mice (model of diabetes) and control db/+ littermates
Comparison
Cardiac magnetic resonance imaging at 5, 9, 13… vs Control db/+ littermates
Design
Preclinical
Follow-up
up to 22 weeks of age
Authors
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Supports db/db mice as a model for diabetic cardiomyopathy progression; leaves open human translation and clinical relevance.
CMR imaging demonstrates that db/db mice develop progressive structural and functional changes consistent with diabetic cardiomyopathy, with hypertrophy preceding systolic dysfunction.
Yue et al. (2006) studied Diabetes-induced cardiomyopathy. Cardiac magnetic resonance (CMR) imaging vs. Control db/+ littermates was evaluated on Left ventricular mass, wall thickness, end-diastolic volume, and ejection fraction. Cardiac magnetic resonance imaging of female db/db mice demonstrated significant increases in left ventricular mass and wall thickness by 9 weeks, and a significant decrease in LVEF by 22 weeks.
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