What question did this study set out to answer?

To characterize the cardiovascular and autonomic phenotype of male db/db diabetic mice across aging and determine the therapeutic contribution of angiotensin II type 1 receptor blockade.

February 14, 2009Journal of Bioresource ManagementOpen Access

Cardiovascular and autonomic phenotype of db/db diabetic mice

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Why the study?

Does losartan prevent the age-related increase in mean arterial pressure in male db/db diabetic mice?

Key Points

To characterize the cardiovascular and autonomic phenotype of male db/db diabetic mice across aging and determine the therapeutic contribution of angiotensin II type 1 receptor blockade.
Monitored 24-hour mean arterial pressure (MAP), heart rate, and circadian rhythms using radiotelemetry over 8 weeks in male db/db and age-matched control mice.
Administered chronic treatment with the angiotensin II type 1 receptor antagonist losartan (10 mg/kg/day) to evaluate changes in MAP.
Assessed autonomic function through spectral analysis of blood pressure variance alongside measurements of plasma angiotensin-converting enzyme activity and angiotensin II concentrations.
By 14 weeks of age, MAP was significantly elevated in db/db mice compared to controls during both the light phase (117 ± 2 vs. 101 ± 1 mmHg, P < 0.01) and dark phase (121 ± 3.1 vs. 110 ± 1.7 mmHg, P < 0.01).
The age-associated rise in MAP coincided with marked increases in plasma angiotensin-converting enzyme activity and angiotensin II levels, and chronic losartan fully prevented this blood pressure elevation in db/db mice.
Spectral analysis revealed an absence of the normal circadian rhythm in systolic arterial pressure variance and its low-frequency component in db/db mice, despite unchanged heart rate variability and spontaneous baroreflex sensitivity.

Structured PICO

Does losartan prevent the age-related increase in mean arterial pressure in male db/db diabetic mice?

Population

Male db/db mice (model for type 2 diabetes characterized by hyperinsulinaemia and progressive hyperglycaemia)

Intervention

Losartan (10 mg/kg/day) chronic treatment

Comparator

Age-matched control mice and untreated db/db mice

Outcome

24-hour blood pressure (mean arterial pressure), heart rate, and their variabilities measured by radiotelemetrysurrogate

The db/db mouse model of type 2 diabetes exhibits an age-related increase in mean arterial pressure and altered autonomic balance, which can be mitigated by angiotensin II AT1 receptor antagonism with losartan.

Discussion

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Implication

Losartan attenuates diabetic hypertension in mice; leaves open translation to human type 2 diabetes management.

Cite This Study

Senador et al. (2009) studied this question.

synapsesocial.com/papers/6a761a11d5b06e2c1e61429b https://doi.org/10.1113/expphysiol.2008.046474

Topics

Hypertension management

View Full Paper

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Cardiovascular and autonomic phenotype of db/db diabetic mice

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Cardiovascular and autonomic phenotype of db/db diabetic mice

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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