Key result
Leptin receptor-deficient db/db mice exhibited higher resting blood pressure (117 vs 108 mm Hg) and altered autonomic responses compared to db/+ mice, which were improved by enalapril.
Why the study?
Does renin-angiotensin system blockade with enalapril improve autonomic regulation in leptin receptor-deficient db/db mice?
Population
Leptin receptor-deficient db/db mice and db/+ control mice
Comparison
Pharmacological autonomic assessment… vs db/+ mice (controls)
Design
Preclinical
Authors
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Enalapril improved autonomic responses in db/db mice; hypothesis-generating for RAS blockade in human diabetic autonomic neuropathy.
Does renin-angiotensin system blockade with enalapril improve autonomic regulation in leptin receptor-deficient db/db mice?
Absolute Event Rate: 117% vs 108%
Leptin receptor-deficient db/db mice exhibit autonomic dysfunction similar to human type 2 diabetic autonomic neuropathy, which is improved by renin-angiotensin system blockade.
Gonçalves et al. (2008) studied Type 2 diabetes mellitus, hypertension, and obesity. Leptin receptor deficiency (db/db genotype) vs. db/+ genotype was evaluated on Resting period blood pressure (mm Hg). Leptin receptor-deficient db/db mice exhibited higher resting blood pressure (117 vs 108 mm Hg) and altered autonomic responses compared to db/+ mice, which were improved by enalapril.
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