Key result
Mean arterial blood pressure was not significantly different between db/db and db/m mice (113 ± 3 vs. 112 ± 2 mmHg), and afferent arteriole responses to renal perfusion pressure remained intact.
Absolute Event Rate: 113% vs 112%
p-value: p=not significant
Diabetic renal disease occurs in db/db mice independently of elevated blood pressure, with intact afferent arteriole autoregulatory responsiveness.
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Diabetic nephropathy may progress without hypertension or autoregulatory loss in mice; leaves open primary mechanisms and human relevance.
Park et al. (2008) studied Type 2 diabetes (animal model) (n=21). db/db genotype (type 2 diabetes model) vs. db/m (lean littermate control) mice was evaluated on Mean arterial blood pressure (mmHg) (p=not significant). Mean arterial blood pressure was not significantly different between db/db and db/m mice (113 ± 3 vs. 112 ± 2 mmHg), and afferent arteriole responses to renal perfusion pressure remained intact.
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