Key result
In mice with Type 2 diabetes, systolic and mean arterial pressures were significantly elevated compared to controls (P<0.05), driven by enhanced COX-2-dependent production of constrictor prostaglandins.
Population
Mice with Type 2 diabetes mellitus (C57BL/KsJ-(db-)/db-) and control (db+/db-) animals
Comparison
In vitro application of SQ29548, SC-560, or… vs Control mice (db+/db-) and untreated vessels
Design
Preclinical
Authors
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COX-2 inhibition may lower vascular resistance in diabetic hypertension; leaves open translation to human Type 2 diabetes.
p-value: p=<0.05
In a mouse model of Type 2 diabetes, increased basal tone of skeletal muscle arterioles and elevated blood pressure are driven by enhanced COX-2-dependent production of constrictor prostaglandins.
Bagi et al. (2005) studied Type 2 diabetes mellitus. Type 2 diabetes mellitus (db/db genotype) vs. Control (db+/db-) mice was evaluated on Systolic and mean arterial pressures (p=<0.05). In mice with Type 2 diabetes, systolic and mean arterial pressures were significantly elevated compared to controls (P<0.05), driven by enhanced COX-2-dependent production of constrictor prostaglandins.
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