Why the study?
Does biventricular volume overload alter the intrinsic contractile performance of isolated right and left ventricular cardiocytes in a feline model?
Population
Feline model of biventricular volume overload (n=7 cats) and sham-operated controls (n=7)
Comparison
Peripheral arteriovenous fistula producing… vs Sham-operated cats
Design
Preclinical
Authors
Loading...
Preserved cellular contractility despite feline volume-overload hypertrophy; leaves open translation to human biventricular states.
Does biventricular volume overload alter the intrinsic contractile performance of isolated right and left ventricular cardiocytes in a feline model?
Contractile dysfunction is not an inherent property of RV or LV cardiocytes hypertrophying in response to substantial volume overloading with normal afterload.
Urabe et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: