Key result
An elevated platelet to lymphocyte ratio was significantly associated with stable coronary artery disease compared with non-CAD controls (P=0.002), and correlated with severe atherosclerosis (P<0.001).
Why the study?
Recent studies reported a relationship between platelet to lymphocyte ratio and acute coronary syndromes, but its association with stable CAD required investigation.
Is an elevated platelet to lymphocyte ratio associated with the presence and severity of stable coronary artery disease?
Population
4,871 patients across 14 studies
Comparison
CAD vs non-CAD groups
Design
Meta-analysis of observational studies
Authors
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May refine stable CAD risk stratification; extends observational meta-analyses but requires prospective validation.
Meta-Analysis (n=4,871)
Is an elevated platelet to lymphocyte ratio associated with the presence and severity of stable coronary artery disease?
p-value: p=.002
An elevated platelet to lymphocyte ratio is associated with the presence and severity of stable coronary artery disease, suggesting its potential utility as a biomarker.
Qiu et al. (2020) conducted a meta-analysis in Stable coronary artery disease (CAD) (n=4,871). Platelet to lymphocyte ratio (PLR) vs. Non-CAD group was evaluated on Association between PLR and stable CAD (p=.002). An elevated platelet to lymphocyte ratio was significantly associated with stable coronary artery disease compared with non-CAD controls (P=0.002), and correlated with severe atherosclerosis (P<0.001).
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