Key result
A higher platelet-to-lymphocyte ratio was independently associated with poor coronary collateral circulation in patients with NSTEMI (OR 1.51 per 10-unit increase).
Why the study?
Does a high platelet-to-lymphocyte ratio predict poor coronary collateral circulation in patients with NSTEMI?
Observational (n=386)
No
Does a high platelet-to-lymphocyte ratio predict poor coronary collateral circulation in patients with NSTEMI?
Odds Ratio: 1.51 (95% CI 1.27–1.74)
p-value: p=<0.001
A higher platelet-to-lymphocyte ratio is independently associated with poor coronary collateral circulation in patients with NSTEMI, suggesting its potential utility as a simple, inexpensive prognostic marker.
PLR should not yet guide NSTEMI decisions; hypothesis-generating for its role in CCC risk stratification.
INTRODUCTION: Recently, platelet-to-lymphocyte ratio (PLR) has emerged as a significant inflammatory marker and a novel predictor of major adverse consequences in cardiovascular disease. AIM: In this study, we aimed to explore the relationship between PLR and coronary collateral circulation (CCC) in patients with non-ST elevation myocardial infarction (NSTEMI). MATERIAL AND METHODS: Clinical and laboratory data of 386 patients who underwent coronary angiography were evaluated retrospectively. The patients were classified into 2 groups as follows: poor CCC (group 1: Rentrop grades 0-1) and good CCC (group 2: Rentrop grades 2-3). The PLR was calculated from the complete blood count. RESULTS: The PLR values of the patients with poor CCC were significantly higher than those of patients with good CCC (153.9 ±26.6 vs. 129.8 ±23.5, p < 0.001). In the multiple logistic regression tests, PLR (odds ratio: 1.51, 95% confidence interval: 1.27-1.74; p < 0.001) and hs-CRP (odds ratio: 1.56, 95% CI: 1.03-2.11; p < 0.001) were found to be independent predictors of poor CCC. The receiver operating characteristic (ROC) curve analysis yielded a cutoff value of 140.5 for PLR to predict poor CCC with 79% sensitivity and 71% specificity, with the area under the ROC curve being 0.792 (95% CI: 0.721-0.864). CONCLUSIONS: Our study revealed that high PLR is independently associated with poor coronary collateral circulation in patients with NSTEMI.
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Akdağ et al. (2016) conducted an observational in Non-ST segment elevation myocardial infarction (NSTEMI) (n=386). Platelet-to-lymphocyte ratio (PLR) vs. Lower PLR was evaluated on Poor coronary collateral circulation (Rentrop grades 0-1) (OR 1.51, 95% CI 1.27-1.74, p=<0.001). A higher platelet-to-lymphocyte ratio was independently associated with poor coronary collateral circulation in patients with NSTEMI (OR 1.51 per 10-unit increase).
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