Key result
Longer nocturnal BP surge duration is linked to increased arterial stiffness independent of BP variability.
Why the study?
Nocturnal blood pressure surge in seconds is induced by obstructive sleep apnea and sympathetic hyperactivity, but its relationship with arterial stiffness was not well defined.
Is the upward duration of nocturnal blood pressure surge in seconds associated with arterial stiffness in patients with suspected obstructive sleep apnea?
Cross-Sectional (n=34)
Is the upward duration of nocturnal blood pressure surge in seconds associated with arterial stiffness in patients with suspected obstructive sleep apnea?
Effect estimate: β = 0.365 (95% CI 0.006-0.725)
p-value: p=0.046
The upward duration of nocturnal blood pressure surges in seconds may be a novel marker for arterial stiffness and cardiovascular risk in patients with suspected OSA.
May mark arterial stiffness in suspected OSA; hypothesis-generating and requires prospective validation before clinical use.
Nocturnal blood pressure (BP) surge in seconds (sec-surge), which is characterized as acute transient BP elevation over several tens of seconds is induced by obstructive sleep apnea (OSA) and OSA-related sympathetic hyperactivity. The authors assessed the relationship between sec-surge and arterial stiffness in 34 nocturnal hypertensive patients with suspected OSA (mean age 63.9 ± 12.6 years, 32.4% female). During the night, they had beat-by-beat (BbB) BP and cuff-oscillometric BP measurements, and brachial-ankle pulse wave velocity (baPWV) was assessed as an arterial stiffness index. Multiple linear regression analysis revealed that the upward duration (UD) of sec-surge was significantly associated with baPWV independently of nocturnal oscillometric systolic BP variability (β = .365, p = .046). This study suggests that the UD of sec-surge, which can only be measured using a BbB BP monitoring device, may be worth monitoring in addition to nocturnal BP level.
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Kokubo et al. (2023) conducted a cross-sectional in Nocturnal hypertension with suspected obstructive sleep apnea (n=34). Upward duration of nocturnal blood pressure surge in seconds (sec-surge) was evaluated on Arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) (β = 0.365, 95% CI 0.006-0.725, p=0.046). The upward duration of nocturnal blood pressure surge in seconds was significantly associated with arterial stiffness independently of nocturnal systolic blood pressure variability (β = 0.365, p = 0.046).
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