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January 1, 2001Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Antibodies to Oxidized LDL in Relation to Intima-Media Thickness in Carotid and Femoral Arteries in 58-Year-Old Subjectively Clinically Healthy Men

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Why the study?

Are IgG and IgM antibody titers to oxidized LDL associated with intima-media thickness in the carotid and femoral arteries in healthy 58-year-old men?

Population

58-year-old subjectively clinically healthy men recruited from the general population

Design

Cross-sectional

Authors

JHJohannes HultheAntaros Medical (Sweden)LBLena BokemarkGeneral / Preventive / LipidsBFBjörn FagerbergGeneral / Preventive / Lipids

Discussion

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Implication

OxLDL Ab–IMT associations are not independent of risk factors; hypothesis-generating and requires prospective confirmation before clinical consideration.

Structured PICO

Are IgG and IgM antibody titers to oxidized LDL associated with intima-media thickness in the carotid and femoral arteries in healthy 58-year-old men?

P
Population
58-year-old subjectively clinically healthy men recruited from the general population
I
Intervention
IgG and IgM antibody titers to oxidized low density lipoprotein (OxLDL)
O
Outcome
Intima-media thickness (IMT) in the carotid and femoral arteries measured by ultrasoundsurrogate

Antibodies to oxidized LDL correlate with intima-media thickness in carotid and femoral arteries in healthy men, but these associations are driven by traditional cardiovascular risk factors rather than being independent predictors.

Cite This Study

Hulthe et al. (2001) studied this question.

synapsesocial.com/papers/6a1d9951750575be8d2fa645https://doi.org/10.1161/01.atv.21.1.101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,728 citations
  2. 2Presence of autoantibodies against oxidatively modified low-density lipoprotein in essential hypertension1995 · 76 citations
  3. 3Autoantibodies to OxLDL Are Decreased in Individuals With Borderline Hypertension1999 · 120 citations
  4. 4Autoantibodies Against Oxidized LDL Do Not Predict Atherosclerotic Vascular Disease in Non–Insulin-Dependent Diabetes Mellitus1996 · 135 citations
  5. 5Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis.1995 · 597 citations