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This review summarizes current knowledge regarding the role of fibrosis and its detection by gadolinium-enhanced MRI in hypertrophic cardiomyopathy.
Gadolinium-enhanced MRI is a promising imaging technique for detecting cardiac fibrosis, which may help refine the clinical management of patients with hypertrophic cardiomyopathy.
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Gadolinium MRI may refine fibrosis assessment in HCM; leaves open its integration into management without prospective trials.
Fibroblast activity within the heart may be considered a basically constructive process. Hyperactivity of fibroblasts, however, may result in the accumulation of extracellular matrix proteins with adverse effects on cardiac structure and function including electrical instability and increased risk of arrhythmogenic cardiac death. The detection of cardiac fibrosis by dedicated imaging techniques, mainly gadolinium-enhanced MRI, holds promise to refine patient management in a variety of cardiac conditions. This review aims to summarize the current knowledge regarding fibrosis in hypertrophic cardiomyopathy.
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Prinz et al. (2013) conducted a review in Hypertrophic cardiomyopathy. This review summarizes current knowledge regarding the role of fibrosis and its detection by gadolinium-enhanced MRI in hypertrophic cardiomyopathy.
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