What is the clinical evidence from this study?

Study design: Observational. Population: Advanced systolic heart failure (n=98). Intervention: Arterial stiffness measurement (Augmentation index and Pulse wave velocity). Primary outcome: Mortality (OR 1.128, 95% CI 1.026-1.240, p=0.013).

What does this research mean for the field?

Arterial stiffness, measured by augmentation index and pulse wave velocity, is an independent predictor of mortality in patients with advanced systolic heart failure. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 11, 2013Cardiology JournalOpen Access

The prognostic value of arterial stiffness in systolic heart failure

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Key result

Increased arterial stiffness, measured by augmentation index (OR 1.128) and pulse wave velocity, was a strong independent predictor of mortality in patients with advanced heart failure.

Why the study?

Does increased arterial stiffness predict mortality in patients with advanced systolic heart failure?

Population

98 patients with advanced systolic heart failure, mean age 59.4 years, 76 males. Excluded: atrial…

Design

Cohort

Follow-up

18 months

Authors

ŞDŞerafettin DemirState Hospital OAOnur AkpınarBakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi OAOğuz AkkuşMustafa Kemal University

Discussion

Member takes

Implication

May aid risk stratification in advanced HF; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=98)

Structured PICO

Does increased arterial stiffness predict mortality in patients with advanced systolic heart failure?

Population

98 patients with advanced systolic heart failure (NYHA class III-IV, LVEF ≤ 35% due to ischemic cardiomyopathy), mean age 59.4 years, 76 males. Excluded: atrial fibrillation, frequent ventricular ectopic beats, advanced renal failure (serum creatinine > 2.0 mg/dL), thyroid disease, respiratory diseases, primary pulmonary hypertension, acute coronary syndrome within the last 2 months, isolated right HF, congenital cardiac diseases, and advanced valvular disease.

Intervention

Measurement of arterial stiffness using augmentation index (Aix) and pulse wave propagation velocity (PWV) via arteriography

Outcome

Mortality at 18-month follow-uphard clinical

Main Result

Effect estimate: OR 1.128 (95% CI 1.026-1.240)

p-value: p=0.013

Increased arterial stiffness, measured by augmentation index and pulse wave velocity, is a strong, independent predictor of 18-month mortality in patients with advanced systolic heart failure.

Limitations

Small sample size of 98 patients
Could not evaluate patients with ventricular and supraventricular arrhythmias by arteriograph
Small sample size (n=98)
Could not evaluate patients with arrhythmias (ventricular and supraventricular) by arteriograph

Cite This Study

Demir et al. (2013) conducted an observational in Advanced systolic heart failure (n=98). Arterial stiffness measurement (Augmentation index and Pulse wave velocity) was evaluated on Mortality (OR 1.128, 95% CI 1.026-1.240, p=0.013). Increased arterial stiffness, measured by augmentation index (OR 1.128) and pulse wave velocity, was a strong independent predictor of mortality in patients with advanced heart failure.

synapsesocial.com/papers/6a1da0445b7fddc352058698 https://doi.org/10.5603/cj.2013.0168

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The prognostic value of arterial stiffness in systolic heart failure

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

The prognostic value of arterial stiffness in systolic heart failure

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider