Key result
Captopril improved scopolamine-induced memory impairment in rats, reducing latency and distance to the platform in the Morris Water Maze test (P < .05 to P < .001) and improving BDNF and oxidative stress markers.
Why the study?
The effects of BDNF, cytokines, and the renin angiotensin system on memory function have been demonstrated, but captopril's specific effects on hippocampal markers in scopolamine-induced memory impairment warranted examination.
Does captopril improve memory impairment and alter neuroinflammation and oxidative stress in scopolamine-treated rats?
Population
Rats with scopolamine-induced memory impairment
Comparison
Captopril (10, 50, or 100 mg/kg) plus scopolamine vs scopolamine alone vs control
Design
Animal experimental study
Authors
Loading...
Captopril merits human trials in cognitive impairment; animal data leave open clinical translation for memory or oxidative stress.
Does captopril improve memory impairment and alter neuroinflammation and oxidative stress in scopolamine-treated rats?
p-value: p=<.05 to <.001
Captopril improves scopolamine-induced memory impairment in rats, potentially through modulation of BDNF, neuroinflammation, and oxidative stress.
Beheshti et al. (2021) studied Scopolamine-induced memory impairment. Captopril vs. Scopolamine alone and control was evaluated on Morris Water Maze test performance and biochemical markers (BDNF, IL-6, NO metabolites, MDA, thiol, SOD, CAT) (p=<.05 to <.001). Captopril improved scopolamine-induced memory impairment in rats, reducing latency and distance to the platform in the Morris Water Maze test (P < .05 to P < .001) and improving BDNF and oxidative stress markers.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: