Key result
The ACE I/D polymorphism was significantly associated with an increased risk of Kawasaki disease under the dominant model (OR 1.43).
Why the study?
Does the ACE I/D polymorphism increase susceptibility to Kawasaki disease in Asian populations?
Meta-Analysis (n=1,092)
Does the ACE I/D polymorphism increase susceptibility to Kawasaki disease in Asian populations?
Effect estimate: OR 1.43 (95% CI 1.11-1.85)
The ACE I/D polymorphism, particularly the DI genotype and dominant model, is significantly associated with an increased risk of Kawasaki disease in Asian populations.
Supports ACE I/D screening hypothesis in Asian Kawasaki disease; leaves open prospective validation before clinical use.
BACKGROUND: The angiotensin-converting enzyme (ACE) I/D polymorphism has been reported to be associated with Kawasaki disease (KD), but studies to date present conflicting results. OBJECTIVES: The aim of this study is to derive a more precise estimation of the association between the ACE I/D polymorphism and KD risk. METHODS: PubMed, EMBASE, CNKI and Wangfang databases were retrievaled to identify for relevant studies from inception to May 2017. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using Stata 12.0 software. RESULTS: A total of 6 case-control studies comprising 634 patients and 458 controls were included in the meta-analysis, and we found a significant association between the ACE I/D polymorphism and KD risk (D vs I:OR = 0.81, 95%CI = 0.31-2.11;DD vs II: OR = 1.03, 95%CI = 0.42-2.54; DI vs II: OR = 1.44, 95%CI = 1.09-1.90; dominant model: OR = 1.43, 95%CI = 1.11-1.85; recessive model: OR = 1.21, 95%CI = 0.44-3.29 ). When stratified by sample size>200, this polymorphism is associated with an increased the risk of KD. CONCLUSION: The I/D polymorphism in the ACE gene may be associated with susceptibility to KD.
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Pan et al. (2018) conducted a meta-analysis in Kawasaki disease (n=1,092). ACE I/D polymorphism vs. Healthy controls was evaluated on Kawasaki disease risk (dominant model) (OR 1.43, 95% CI 1.11-1.85). The ACE I/D polymorphism was significantly associated with an increased risk of Kawasaki disease under the dominant model (OR 1.43).
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