What is the clinical evidence from this study?

Study design: Case-Control. Population: Kawasaki disease (n=98). Intervention: ACE gene ID genotype vs. Healthy children (control group). Primary outcome: Prevalence of ACE ID genotype (OR 3.3, p=<0.01).

January 1, 2006Journal of Korean Medical ScienceOpen Access

Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene in Kawasaki Disease

Q: What are the key findings of this study?

The ID genotype of the ACE gene was significantly more prevalent in children with Kawasaki disease compared to healthy controls (60.0% vs 30.2%, OR 3.3, p<0.01).

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Key result

ACE gene ID genotype linked to ~230% higher odds of Kawasaki disease in children.

OR 3.3
P<0.01
n=98

Why the study?

Is the ACE gene insertion/deletion polymorphism associated with Kawasaki disease and the development of coronary dilatations in children?

Population

55 children with Kawasaki disease and 43 healthy children from Korea.

Comparison

Angiotensin converting enzyme gene… vs Healthy children (control group)

Design

Case-control

Authors

YSYoon Hee ShimEwha Womans University HKHae Soon KimEwha Womans University SSSejung SohnEwha Womans University

Discussion

Member takes

Implication

ACE ID genotype associated with Kawasaki disease susceptibility but not dilatations in Korean children; leaves open causal role and clinical utility pending replication.

Study Design

Type

Case-Control (n=98)

Multicenter

Structured PICO

Is the ACE gene insertion/deletion polymorphism associated with Kawasaki disease and the development of coronary dilatations in children?

Population

98 Korean children, including 55 with Kawasaki disease and 43 healthy controls, evaluated for the association between ACE gene I/D polymorphism and Kawasaki disease.

Exposure

Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism evaluation

Comparator

Healthy children (control group)

Outcome

Frequencies of ACE genotypes (DD, ID, II) and alleles (I, D) in Kawasaki disease patients versus controls, and in Kawasaki patients with versus without coronary dilatationssurrogate

Main Result

Odds Ratio: 3.3

Absolute Event Rate: 60% vs 30.2%

p-value: p=<0.01

The ACE gene I/D polymorphism is associated with the prevalence of Kawasaki disease in Korean children, but not with the development of coronary artery dilatations.

Limitations

Relatively small sample size
Selection bias caused by a limited number of enrolled institutions
Results may not be generalizable due to different ethnic traits compared to other populations
Small sample size making it difficult to generalize results
Selection bias caused by limited number of enrolled institutions

Cite This Study

Shim et al. (2006) conducted a case-control in Kawasaki disease (n=98). ACE gene ID genotype vs. Healthy children (control group) was evaluated on Prevalence of ACE ID genotype (OR 3.3, p=<0.01). The ID genotype of the ACE gene was significantly more prevalent in children with Kawasaki disease compared to healthy controls (60.0% vs 30.2%, OR 3.3, p<0.01).

synapsesocial.com/papers/6aa3cd989fb7966fc9749600 https://doi.org/10.3346/jkms.2006.21.2.208

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January 1, 2006Journal of Korean Medical ScienceOpen Access

Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene in Kawasaki Disease

View Full Paper

Ask AI

Bookmark

Key result

ACE gene ID genotype linked to ~230% higher odds of Kawasaki disease in children.

OR 3.3
P<0.01
n=98

Why the study?

Is the ACE gene insertion/deletion polymorphism associated with Kawasaki disease and the development of coronary dilatations in children?

Population

55 children with Kawasaki disease and 43 healthy children from Korea.

Comparison

Angiotensin converting enzyme gene… vs Healthy children (control group)

Design

Case-control

Authors

YSYoon Hee ShimEwha Womans University HKHae Soon KimEwha Womans University SSSejung SohnEwha Womans University

Discussion

Member takes

Implication

ACE ID genotype associated with Kawasaki disease susceptibility but not dilatations in Korean children; leaves open causal role and clinical utility pending replication.

Study Design

Type

Case-Control (n=98)

Multicenter

Structured PICO

Is the ACE gene insertion/deletion polymorphism associated with Kawasaki disease and the development of coronary dilatations in children?

Population

98 Korean children, including 55 with Kawasaki disease and 43 healthy controls, evaluated for the association between ACE gene I/D polymorphism and Kawasaki disease.

Exposure

Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism evaluation

Comparator

Healthy children (control group)

Outcome

Frequencies of ACE genotypes (DD, ID, II) and alleles (I, D) in Kawasaki disease patients versus controls, and in Kawasaki patients with versus without coronary dilatationssurrogate

Main Result

Odds Ratio: 3.3

Absolute Event Rate: 60% vs 30.2%

p-value: p=<0.01

The ACE gene I/D polymorphism is associated with the prevalence of Kawasaki disease in Korean children, but not with the development of coronary artery dilatations.

Limitations

Relatively small sample size
Selection bias caused by a limited number of enrolled institutions
Results may not be generalizable due to different ethnic traits compared to other populations
Small sample size making it difficult to generalize results
Selection bias caused by limited number of enrolled institutions

Cite This Study

synapsesocial.com/papers/6aa3cd989fb7966fc9749600 https://doi.org/10.3346/jkms.2006.21.2.208

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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