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January 1, 1998Genes & DevelopmentOpen Access

A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initation of hepatitis C and classical swine fever virus RNAs

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Population

In vitro translation components, hepatitis C virus and classical swine fever virus mRNAs

Design

Preclinical

Authors

TPTatyana V. PestovaBoston UniversityISIvan N. ShatskyLomonosov Moscow State UniversitySFSimon P. FletcherGilead Sciences (United States)

Discussion

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Implication

Supports prokaryotic-like viral initiation; hypothesis-generating for broader eukaryotic translation mechanisms.

Structured PICO

P
Population
In vitro translation components, hepatitis C virus and classical swine fever virus mRNAs
I
Intervention
Reconstitution of internal ribosomal entry
O
Outcome
Assembly of 48S ribosomal preinitiation complexes monitored by toe-printingsurrogate

The eukaryotic initiation mechanism for hepatitis C and classical swine fever virus mRNAs shows striking similarities to prokaryotic translation initiation.

Cite This Study

Pestova et al. (1998) studied this question.

synapsesocial.com/papers/6a1dbe2d95d039da26ef4dafhttps://doi.org/10.1101/gad.12.1.67
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A complex RNA sequence detemines the internal initiation of encephalomyocarditis virus RNA translation1991 · 54 citations
  2. 2Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein1991 · 146 citations
  3. 3Almost the entire 5′ non‐translated region of hepatitis C virus is required for cap‐independent translation1995 · 162 citations
  4. 4Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs1992 · 407 citations