June 1, 1998Journal of VirologyOpen Access

Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs

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Population

Hepatitis C virus (HCV) and classical swine fever virus (CSFV) RNAs

Design

Preclinical

Authors

DSDaria SizovaAlexion Pharma (Switzerland)VKVictoria KolupaevaColumbia University Irving Medical Center TPTatyana V. PestovaBoston University

Discussion

Member takes

Implication

No immediate clinical implications for HCV; hypothesis-generating for IRES-eIF3 interactions and leaves open therapeutic validation.

Structured PICO

Population

Hepatitis C virus (HCV) and classical swine fever virus (CSFV) RNAs

Intervention

Eukaryotic translation initiation factor 3 (eIF3) binding

Outcome

Identification of eIF3 binding sites on HCV and CSFV internal ribosomal entry segments (IRESs)

This study identifies specific binding sites for eIF3 on the IRES elements of HCV and CSFV RNAs, providing a model for how these components enhance translation initiation efficiency.

Cite This Study

Sizova et al. (1998) studied this question.

synapsesocial.com/papers/6a710e09e71d69abee090351 https://doi.org/10.1128/jvi.72.6.4775-4782.1998

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Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider