Why the study?
Does therapy with amlodipine, ramipril, or telmisartan affect the circadian variation of heart rate variability and circulating catecholamines in hypertensive patients?
Population
57 hypertensive patients
Comparison
Amlodipine, ramipril, or telmisartan vs Active comparators
Design
RCT, randomized, open-label
Follow-up
8 weeks
Authors
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May favor telmisartan or ramipril over amlodipine when autonomic effects matter; extends RCT evidence on class-specific HRV and catecholamine modulation.
Does therapy with amlodipine, ramipril, or telmisartan affect the circadian variation of heart rate variability and circulating catecholamines in hypertensive patients?
In hypertensive patients, telmisartan and ramipril improve parasympathetic activity without increasing sympathetic tone, whereas amlodipine causes sympathetic activation and decreases parasympathetic activity.
Karas et al. (2005) studied this question.
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