Why the study?
Do telmisartan or amlodipine improve 24-hour ambulatory blood pressure reduction compared to ramipril in patients with mild-to-moderate hypertension?
Do telmisartan or amlodipine improve 24-hour ambulatory blood pressure reduction compared to ramipril in patients with mild-to-moderate hypertension?
Telmisartan and amlodipine provide sustained 24-hour ambulatory blood pressure reduction when dosed once daily in the morning, whereas ramipril's effect is restricted to its peak, challenging its efficacy as a once-daily morning antihypertensive.
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Telmisartan and amlodipine sustain 24-hour ABP control with morning dosing; challenges ramipril's efficacy as once-daily monotherapy in mild-to-moderate hypertension.
Poirier et al. (2004) studied this question.
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