Key result
Ramipril in combination with telmisartan was equally effective as ramipril alone in reducing systolic blood pressure at 24 weeks (130.72 vs 129.56 mm Hg, p=0.42) in patients with mild to moderate hypertension.
Why the study?
Does the combination of ramipril and telmisartan improve blood pressure reduction compared to ramipril alone in adults with mild to moderate hypertension?
RCT (n=100)
Simple random sampling
No
Does the combination of ramipril and telmisartan improve blood pressure reduction compared to ramipril alone in adults with mild to moderate hypertension?
Absolute Event Rate: 130.72% vs 129.56%
p-value: p=0.42
In patients with mild to moderate hypertension, combining ramipril with telmisartan provides faster initial systolic blood pressure reduction but results in similar 24-week blood pressure control compared to ramipril alone.
No added BP benefit from ramipril-telmisartan combination; leaves open dual blockade efficacy in randomized hypertension trials.
Background: Hypertension is one of the leading causes of the global burden of disease. Hypertension has been associated with increased risk of cardiovascular diseases, including coronary heart disease (CHD), congestive heart failure (CHF), ischemic and hemorrhagic stroke, renal failure, and peripheral arterial disease. Majority of the hypertensive population are still either untreated or inadequately treated. Aims and objectives of the study were to compare ramipril alone and in combination with telmisartan as an antihypertensive in mild to moderate hypertension.Methods: This study was a hospital based prospective, comparative randomized, observational study conducted over a period of one year. The subjects of this study had mild to moderate hypertension selected from outpatient department of department of General Medicine of a tertiary care hospital. For the purpose of this study, equal numbers of subjects were randomly allocated equally between two groups: one group on ramipril alone and the other group on combination of ramipril and telmisartan. Patients were assessed for the blood pressure (BP) reduction during follow-up period of 6-months.Results: Ramipril alone and in combination with telmisartan, both were associated with significant reduction of systolic BP (SBP), diastolic BP (DBP), and mean BP (MBP) from beginning to the end of study. Combination of ramipril with telmisartan was more effective than ramipril in lowering SBP during 4 to 12 weeks but at the end of study both drug groups were found to be equally effective antihypertensive. Both ramipril alone and in combination with telmisartan were equally effective in lowering DBP and MBP from beginning to end of study.Conclusions: There was a significant reduction of SBP, DBP, and MBP from beginning to the end of study with both ramipril alone and in combination with telmisartan. Ramipril alone and in combination with telmisartan, both were equally effective antihypertensive for mild to moderate hypertension.
No takes yet. Share an insight, caveat, or question.
Raja et al. (2017) conducted an RCT in Mild to moderate hypertension (n=100). Ramipril and Telmisartan vs. Ramipril 5 mg once daily was evaluated on Mean systolic blood pressure at 24 weeks (p=0.42). Ramipril in combination with telmisartan was equally effective as ramipril alone in reducing systolic blood pressure at 24 weeks (130.72 vs 129.56 mm Hg, p=0.42) in patients with mild to moderate hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: