Key result
Combination therapy with ramipril and hydrochlorothiazide maintained stable mean blood pressures below 150/85 mmHg over 1 year, with high response rates of 84-95% across all groups.
Why the study?
Does long-term treatment with ramipril alone or combined with hydrochlorothiazide maintain blood pressure reduction in mild to moderate hypertension?
Population
159 patients with mild to moderate hypertension
Design
Cohort, open-label
Follow-up
up to 1 year
Authors
Loading...
Supports sustained BP control with ramipril ± HCTZ; extends short-term data but leaves open need for randomized confirmation.
Cohort (n=159)
Open-label
Yes
Does long-term treatment with ramipril alone or combined with hydrochlorothiazide maintain blood pressure reduction in mild to moderate hypertension?
Long-term treatment with ramipril alone or in combination with hydrochlorothiazide is well tolerated and maintains effective blood pressure control in patients with mild to moderate hypertension.
Heidbreder et al. (1993) conducted a cohort in mild to moderate hypertension (n=159). Combination of ramipril and hydrochlorothiazide vs. ramipril monotherapy (5 mg once daily) was evaluated on blood pressure reduction and response rates. Combination therapy with ramipril and hydrochlorothiazide maintained stable mean blood pressures below 150/85 mmHg over 1 year, with high response rates of 84-95% across all groups.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: