What does this research mean for the field?

Exposure to ultraviolet excimer laser energy causes a dose-dependent suppression of platelet aggregation and contractile force development, a phenomenon termed 'stunned platelets.' Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2001Thrombosis and Haemostasis

Alterations of Platelet Aggregation Kinetics with Ultraviolet Laser Emission: The “Stunned Platelet” Phenomenon

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Why the study?

Does ultraviolet excimer laser emission alter platelet aggregation kinetics and force development in whole blood samples?

Population

Whole blood samples obtained by aseptic venipuncture and anticoagulated with 3.8% sodium citrate

Comparison

Exposure to increased levels of ultraviolet… vs 0 mJ/mm2 (no laser exposure)

Design

Preclinical

Authors

AMAnthony J. MinisiUnited States Department of Veterans Affairs NBNelson L. BernardoMedStar Washington Hospital Center RMRichard A. McPhersonNew Mexico State University

Discussion

Member takes

Implication

May suppress platelet aggregation in animal models; leaves open clinical antithrombotic relevance.

Structured PICO

Does ultraviolet excimer laser emission alter platelet aggregation kinetics and force development in whole blood samples?

Population

Whole blood samples obtained by aseptic venipuncture and anticoagulated with 3.8% sodium citrate

Intervention

Exposure to increased levels (30, 45, 60 mJ/mm2; 25 Hz) of ultraviolet excimer laser fluence (308 nm wave-length)

Comparator

0 mJ/mm2 (no laser exposure)

Outcome

ADP and collagen induced platelet aggregation, platelet concentration, and platelet contractile force (PCF) developmentsurrogate

Ultraviolet excimer laser energy produces a dose-dependent suppression of platelet aggregation and contractile force, demonstrating a 'stunned platelet' phenomenon.

Cite This Study

Minisi et al. (2001) studied this question.

synapsesocial.com/papers/6a1dd6a7cd67cee37334eb80 https://doi.org/10.1055/s-0037-1616537

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Alterations of Platelet Aggregation Kinetics with Ultraviolet Laser Emission: The “Stunned Platelet” Phenomenon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alterations of Platelet Aggregation Kinetics with Ultraviolet Laser Emission: The “Stunned Platelet” Phenomenon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider