Why the study?
The exact subtypes of cell membrane receptors triggering ischemic postconditioning remain controversial or uninvestigated.
Does ischemic postconditioning reduce myocardial infarct size in wild-type and specific receptor knockout mice?
Does ischemic postconditioning reduce myocardial infarct size in wild-type and specific receptor knockout mice?
Ischemic postconditioning-induced cardioprotection against reperfusion injury is mediated by the activation of adenosine A1 and bradykinin B2 receptors.
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Indicates A1/B2 receptor dependence of postconditioning in mice; leaves open clinical translation to human reperfusion injury.
Xi et al. (2008) studied this question.
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