August 14, 2010AJP Heart and Circulatory PhysiologyOpen Access

Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts

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Structured PICO

Population

In situ mouse hearts (wild-type C57Bl/6N mice and CD73 knockout mice) undergoing 30 min of regional ischemia

Intervention

Ischemic postconditioning (6 cycles of 10 s of reperfusion and 10 s of coronary occlusion) or pharmacological activation/antagonism of adenosine receptors (BAY60-6583, CGS-21680, NECA, MRS-1754)

Outcome

Infarct sizesurrogate

Simultaneous activation of both A2a and A2b adenosine receptors is required to reduce infarct size during reperfusion in a mouse model of ischemia.

Authors

CMCarmen MethnerOregon Health & Science University KSKatharina SchmidtCenter for Integrated Protein Science Munich MCMichael V. CohenEast Tennessee State University

Discussion

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Implication

Dual A2a/A2b activation may limit infarct size in murine reperfusion injury; leaves open clinical translation and optimal agonist development.

Cite This Study

Methner et al. (2010) studied this question.

synapsesocial.com/papers/6a90e69571e842060670fa26 https://doi.org/10.1152/ajpheart.00181.2010

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Implication

Dual A2a/A2b activation may limit infarct size in murine reperfusion injury; leaves open clinical translation and optimal agonist development.

Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts

Structured PICO

Discussion

Implication

Cite This Study

Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider