Why the study?
Does ischemic postconditioning reduce infarct size in rabbit hearts undergoing ischemia and reperfusion?
Population
In situ rabbit hearts undergoing 30 min of regional ischemia and 3 h of reperfusion
Comparison
Ischemic postconditioning vs Untreated hearts
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Hypothesis-generating in rabbit ischemia-reperfusion; leaves open clinical translation of postconditioning.
Does ischemic postconditioning reduce infarct size in rabbit hearts undergoing ischemia and reperfusion?
Ischemic postconditioning protects rabbit hearts from infarction via a mechanism dependent on the activation of protein kinase C and adenosine A2b receptors.
Philipp et al. (2006) studied this question.
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