Population
Isolated rabbit hearts undergoing 30-min regional ischemia/2-h reperfusion, and nonischemic hearts
Comparison
PKG activator 8--guanosine 3',5'-cyclic… vs Control
Design
Preclinical
Follow-up
2 hours (reperfusion phase)
Authors
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CPT may limit reperfusion injury via A2b/PKC signaling in animals; leaves open clinical translation of PKG activation.
The PKG activator CPT limits infarct size at reperfusion by activating PKC via mitoKATP-dependent redox signaling, sensitizing A2b receptors to endogenous adenosine.
Kuno et al. (2008) studied this question.
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