Why the study?
Does prior activation of protein kinase C enhance adenosine-induced cardioprotection during simulated ischaemia in cultured chick ventricular cells?
Population
Cultured chick ventricular cell model for simulated ischaemia and preconditioning
Comparison
5 min exposure to PMA prior to a 90 min period… vs Myocytes without prior PMA exposure, or myocytes…
Design
Preclinical
Authors
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May potentiate adenosine cardioprotection in ischaemia; hypothesis-generating for PKC-KATP modulation, requiring mammalian and clinical validation.
Does prior activation of protein kinase C enhance adenosine-induced cardioprotection during simulated ischaemia in cultured chick ventricular cells?
Prior activation of protein kinase C enhances adenosine-induced cardioprotection via sustained KATP channel activation in a preclinical model of ischaemia.
Bruce T. Liang (1998) studied this question.
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