Key result
Late systolic central hypertension is linked to ~22% higher incident heart failure risk.
Why the study?
Does late systolic central hypertension predict incident heart failure in the general population?
Cohort (n=6,124)
Yes
Does late systolic central hypertension predict incident heart failure in the general population?
Hazard Ratio: 1.22 (95% CI 1.15–1.29)
p-value: p=<0.0001
Late systolic central hypertension is a strong, independent predictor of incident heart failure in the general population, outperforming standard hypertension.
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May refine HF risk stratification beyond brachial BP; hypothesis-generating for central pressure-targeted trials.
Chirinos et al. (2015) conducted a cohort in General population free of cardiovascular disease (n=6,124). Late systolic central hypertension (L/E SPTI) vs. Per 1% increase in L/E SPTI was evaluated on Incident heart failure (HR 1.22, 95% CI 1.15-1.29, p=<0.0001). Late systolic central hypertension independently predicted incident heart failure, with a 22% increased risk per 1% increase in the late/early systolic pressure-time integral ratio (HR 1.22).
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