Zofenopril Plus Hydrochlorothiazide Fixed Combination in the Treatment of Hypertension and Associated Clinical Conditions
Why the study?
Does the fixed combination of zofenopril plus hydrochlorothiazide improve blood pressure reduction compared to monotherapy in patients with hypertension?
Population
Patients with mild-moderate hypertension, including high-risk populations; >600 patients across 3 studies.
Comparison
Zofenopril 30 mg plus hydrochlorothiazide 12.5… vs Monotherapy with either zofenopril or…
Design
Review
Authors
Discussion
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Member takes
Implication
May support fixed combination in high-risk hypertension; leaves open need for prospective randomized confirmation.
Structured PICO
Does the fixed combination of zofenopril plus hydrochlorothiazide improve blood pressure reduction compared to monotherapy in patients with hypertension?
P
Population
Patients with mild-moderate hypertension, including high-risk populations (metabolic syndrome, impaired fasting glucose or diabetes, atherogenic dyslipidemia, and impaired renal function); >600 patients across 3 studies.
I
Intervention
Zofenopril 30 mg plus hydrochlorothiazide 12.5 mg once-daily combination
C
Comparator
Monotherapy with either zofenopril or hydrochlorothiazide
O
Outcome
Blood pressure reduction (efficacy) and tolerability/safetysurrogate
The fixed combination of zofenopril and hydrochlorothiazide provides effective and safe blood pressure reduction, particularly in high-risk hypertensive patients, compared to monotherapy.
Cite This Study
Omboni et al. (2009) studied this question.