Key result
Massive coronary calcification linked to ~21% higher visceral adipose tissue area in CAD.
Why the study?
The study was conducted to evaluate the relationship of coronary artery calcification and morphometric parameters of local fat depots in patients with coronary heart disease.
Is massive coronary calcification associated with increased local fat depots in patients with stable coronary artery disease?
Cross-Sectional (n=125)
Is massive coronary calcification associated with increased local fat depots in patients with stable coronary artery disease?
Absolute Event Rate: 191.3% vs 158.35%
p-value: p=0.0002
Increased epicardial and perivascular adipose tissue is associated with massive coronary calcification, suggesting its utility as a non-invasive surrogate marker for severe coronary lesions.
Massive coronary calcification was associated with increased visceral fat in stable CAD; hypothesis-generating and should not yet change practice.
Highlights . Taking into account the connection between the increase in the volume of myocardial adipose tissue and vessels with massive calcification of the coronary arteries in coronary heart disease, morphometry of epicardial and perivascular adipose tissue during routine tomographic examinations can be considered as a non-invasive technique for determining a surrogate marker of severe coronary lesion. Aim . To evaluate the relationship of coronary artery calcification (CA) and morphometric parameters of local fat depots in patients with coronary heart disease (CHD). Methods . 125 patients with stable coronary artery disease aged 59±8.9 years were examined. Visualization of local fat depots, abdominal fat depots, and coronary calcification (CC) was performed using multislice computed tomography with subsequent post-processing of images on the Siemens Leonardo workstation (Germany). Non-contrast magnetic resonance imaging of the heart was used to determine the EAT thickness. Results . Coronary calcification was detected in 95.2% of the examined patients with coronary artery disease (n = 119). There were higher indices of the EAT thickness of the right and left ventricles in case of massive CC, the thickness of the pericardial adipose tissue at the level of the trunk of the left coronary, anterior descending, circumflex arteries, and increased morphometry indices of the abdominal fat depot in comparison with the patients who had moderate and medium CC. Conclusion . An increase in the volume of adipose tissue of the myocardium and vessels in CAD is associated with massive calcification, which is reflected in the pathogenetic “adipovascular” continuum, characterized by the stimulation of adipogenesis against the background of atherocalcinosis of the coronary arteries. Morphometry of epicardial and perivascular adipose tissue during routine tomographic studies is a non-invasive technique for determining a surrogate marker of severe coronary lesions.
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Brel et al. (2022) conducted a cross-sectional in Stable coronary artery disease (n=125). Massive coronary calcification vs. No, minimal, medium, or moderate coronary calcification was evaluated on Visceral adipose tissue (VAT) area (p=0.0002). Massive coronary calcification in patients with coronary artery disease was associated with significantly increased visceral adipose tissue area (191.3 vs 158.35 cm2, p=0.0002) and other local fat depots.
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