Key result
An increment in overall peri-coronary epicardial adipose tissue thickness was associated with a 49% increase in the odds of having coronary artery calcification (OR 1.49).
Why the study?
The study aimed to evaluate the correlation between pericardial fat pad volume, overall peri-coronary EAT thickness, and coronary calcium score to improve risk stratification of CAD.
Cross-Sectional (n=141)
Single-blind
No
Odds Ratio: 1.49 (95% CI 1.13–1.95)
p-value: p=0.004
Peri-coronary epicardial adipose tissue thickness and pericardial fat pad volume measured by MDCT are significantly associated with the presence of coronary artery calcification, suggesting their utility as markers for CAD risk stratification.
May support epicardial fat as CAD marker; hypothesis-generating and requires prospective validation.
BACKGROUND: Coronary artery disease (CAD) is the foremost cause of death in the most developed societies. Plaque formation in epicardial coronary arteries and ensuing inflammation are a known pathophysiologic factor of CAD. OBJECTIVES: We aimed to separately and simultaneously evaluate the correlation between pericardial fat pad volume and overall peri-coronary epicardial adipose tissue (EAT) thickness with coronary calcium score (CCS) to improve risk stratification of CAD. METHODS: We retrospectively reviewed patients who underwent a non-invasive contrast-enhanced coronary multidetector CT (MDCT) angiography. Peri-coronary EAT thickness, pericardial fat pad volume and CCS were obtained by an expert radiologist from the patients coronary multidetector CT (MDCT) angiography. RESULTS: We included 141 symptomatic patients (86 men, 55 women) with an average age of 53.53 ± 12.92. An increment of overall peri-coronary EAT thickness (1/3 × (left anterior descending artery (LAD) + left circumflex artery (LCx) + right coronary artery (RCA)) was associated with a 49% increase in the odds for the presence of coronary artery calcification (CAC) (P = 0.004). Significant predictability of peri-coronary EAT-average was seen in diagnosing calcified plaque. Pericardial fat pad volume was positively correlated with overall peri-coronary EAT thickness in age and body mass index (BMI)-adjusted linear regression models, (P < 0.001). CONCLUSION: Our results amplify previous idea that peri-coronary EAT and pericardial fat pad volume might act as useful markers and better indicators of CCS based on Agatston score in comparison with BMI or body weight in order to reveal subsequent CADs.
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Torkian et al. (2020) conducted a cross-sectional in Suspected coronary artery disease (n=141). Peri-coronary epicardial adipose tissue (EAT) thickness vs. Lower EAT thickness was evaluated on Presence of coronary artery calcification (CAC > 0) (OR 1.49, 95% CI 1.13-1.95, p=0.004). An increment in overall peri-coronary epicardial adipose tissue thickness was associated with a 49% increase in the odds of having coronary artery calcification (OR 1.49).
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