Assay development study demonstrates a rapid microplaque reduction method for human and mouse interferon, suggesting broad utility for high-throughput virological screening.
A microplaque reduction assay for human and mouse interferons is described, using plastic disposable multicompartmental plates with flat-bottomed wells of 6 mm in diameter. The procedure is rapid and reproducible and lends itself to a considerable degree of automation. Its potential application in other areas of virology, such as rapid screening of samples for virus content or assay of neutralizing antibodies, is also discussed.
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Campbell et al. (1975) studied this question.
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