What does this research mean for the field?

Q: What does this research mean for the field?

Tumor necrosis factor (TNF) confers cytoprotection against cardiac ischemia-reperfusion injury through TRAF2-mediated activation of nuclear factor-kappaB. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 31, 2009Circulation Heart FailureOpen Access

The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart

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Structured PICO

Population

Mice with cardiac-restricted overexpression of low levels of TNF (MHCsTNF(3)) and TRAF2 (MHC-TRAF2(LC)) and mice lacking TNFR1, TNFR2, and TNFR1/TNFR2

Intervention

Ischemia (30 minutes) reperfusion (30 minutes) injury ex vivo using a Langendorff apparatus

Comparator

Littermate controls and wild-type mice

Outcome

Left ventricular developed pressure, creatine kinase release, and Evans blue dye uptakesurrogate

TNF confers cytoprotection in the heart against ischemia-reperfusion injury through TRAF2-mediated activation of nuclear factor-kappaB.

Discussion

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Implication

Suggests TNF-TRAF2 cytoprotection in murine I/R; leaves open translation to human therapy.

Cite This Study

Burchfield et al. (2009) studied this question.

synapsesocial.com/papers/6a1dec8b79ea62caf660448d https://doi.org/10.1161/circheartfailure.109.899732

View Full Paper

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The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart

Structured PICO

Discussion

Implication

Cite This Study

The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider