Why the study?
Does cardiac-restricted overexpression of TRAF2 provoke adverse cardiac remodeling in mice?
Does cardiac-restricted overexpression of TRAF2 provoke adverse cardiac remodeling in mice?
Targeted overexpression of TRAF2 is sufficient to mediate adverse cardiac remodeling in the adult mammalian heart.
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TRAF2 overexpression suffices for adverse remodeling in mice; leaves open its relevance as a therapeutic target in human HF.
Divakaran et al. (2013) studied this question.
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