Key result
Cardiac-specific deletion of Traf2 in mice triggered necroptotic cardiac cell death, pathological remodeling, and heart failure, demonstrating its critical role in myocardial survival.
Traf2 plays a critical cardioprotective role by suppressing necroptotic signaling, identifying a potential new therapeutic target for pathological remodeling and heart failure.
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Traf2 modulation may represent a heart failure target; leaves open translation from murine models to patients.
Guo et al. (2017) studied Heart failure and pathological cardiac remodeling. Cardiac-specific deletion of Traf2 was evaluated on Myocardial necroptosis and remodeling. Cardiac-specific deletion of Traf2 in mice triggered necroptotic cardiac cell death, pathological remodeling, and heart failure, demonstrating its critical role in myocardial survival.
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