What does this research mean for the field?

Ketamine and its S(+) isomer precondition isolated human myocardium against hypoxia-reoxygenation injury through the activation of ATP-sensitive potassium channels and alpha- and beta-adrenergic receptors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 17, 2005AnesthesiologyOpen Access

Ketamine Preconditions Isolated Human Right Atrial Myocardium

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Why the study?

Does ketamine precondition isolated human right atrial myocardium against hypoxia-reoxygenation injury?

Population

Isolated human right atrial trabeculae submitted to hypoxia-reoxygenation in vitro

Comparison

Racemic ketamine and its S isomer at various… vs Control group (no ketamine)

Design

Preclinical

Follow-up

60-min reoxygenation period

Authors

JHJean‐Luc HanouzNormandie Université LZLan ZhuShihezi University EPEmmanuel PersehayeMarymount University

Discussion

Member takes

Implication

May support ex vivo preconditioning; leaves open clinical translation to perioperative cardioprotection.

Structured PICO

Does ketamine precondition isolated human right atrial myocardium against hypoxia-reoxygenation injury?

Population

Isolated human right atrial trabeculae submitted to hypoxia-reoxygenation in vitro

Intervention

Racemic ketamine and its S(+) isomer at various concentrations (10^-6, 10^-5, 10^-4 M) alone or with antagonists (5-hydroxydecanoate, HMR 1098, phentolamine, propranolol) for 15 min before a 30-min hypoxic period

Comparator

Control group (no ketamine)

Outcome

Force of contraction at the end of the 60-min reoxygenation periodsurrogate

Ketamine preconditions isolated human myocardium against hypoxia-reoxygenation injury via ATP-sensitive potassium channels and adrenergic receptors.

Cite This Study

Hanouz et al. (2005) studied this question.

synapsesocial.com/papers/6a1df053871ff5209bef922d https://doi.org/10.1097/00000542-200506000-00019

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Ketamine Preconditions Isolated Human Right Atrial Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ketamine Preconditions Isolated Human Right Atrial Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider