What question did this study set out to answer?

To assess the prevalence, severity levels, and associated factors of potential drug-drug interactions among hospitalized pediatric patients.

October 11, 2024BMC PediatricsOpen Access

Potential drug-drug interactions and associated factors among hospitalized pediatric patients in Adigrat general hospital, Tigrai, north Ethiopia: a retrospective cross-sectional study

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Authors

GHGebretekle Gebremichael HailesilaseAdigrat University AKAbrahaley Mulu KidaneAdigrat University HGHaylay Araya GebrezgabiherAdigrat University

Discussion

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Implication

A retrospective cross-sectional study reveals high rates of potential drug-drug interactions in hospitalized pediatric patients, highlighting the need for computerized screening.

Key Points

To assess the prevalence, severity levels, and associated factors of potential drug-drug interactions among hospitalized pediatric patients.
Conducted a retrospective cross-sectional study reviewing medical charts of hospitalized pediatric patients (N=146) from July 1 to August 31, 2020, selected using simple random sampling.
Identified and classified potential drug-drug interactions (pDDIs) using the Micromedex 2.0 database and analyzed associated predictors via multivariable logistic regression.
Of 146 pediatric patients, 68.5% (n=100) experienced at least one pDDI, with 158 total interactions identified across 33 drug pairs (63.3% minor, 25.9% major, and 3.8% contraindicated).
Common clinical consequences included increased risk of QT-interval prolongation (10.1%), theophylline toxicity (5.1%), antiepileptic toxicity (5.1%), and ceftriaxone calcium precipitation (3.8%).
Significant factors associated with pDDI exposure included infant/toddler age (AOR = 31.961, 95% CI: 1.117–914.528), number of diseases (AOR = 0.255, 95% CI: 0.069–0.939), and polypharmacy (AOR = 0.276, 95% CI: 0.091–0.838).

Cite This Study

Hailesilase et al. (2024) studied this question.

synapsesocial.com/papers/6a1e1b72348274ea529fd798 https://doi.org/10.1186/s12887-024-05128-9

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October 11, 2024BMC PediatricsOpen Access

Potential drug-drug interactions and associated factors among hospitalized pediatric patients in Adigrat general hospital, Tigrai, north Ethiopia: a retrospective cross-sectional study

View Full Paper

Ask AI

Bookmark

Authors

GHGebretekle Gebremichael HailesilaseAdigrat University AKAbrahaley Mulu KidaneAdigrat University HGHaylay Araya GebrezgabiherAdigrat University

Discussion

Member takes

Implication

A retrospective cross-sectional study reveals high rates of potential drug-drug interactions in hospitalized pediatric patients, highlighting the need for computerized screening.

Key Points

To assess the prevalence, severity levels, and associated factors of potential drug-drug interactions among hospitalized pediatric patients.
Conducted a retrospective cross-sectional study reviewing medical charts of hospitalized pediatric patients (N=146) from July 1 to August 31, 2020, selected using simple random sampling.
Identified and classified potential drug-drug interactions (pDDIs) using the Micromedex 2.0 database and analyzed associated predictors via multivariable logistic regression.
Of 146 pediatric patients, 68.5% (n=100) experienced at least one pDDI, with 158 total interactions identified across 33 drug pairs (63.3% minor, 25.9% major, and 3.8% contraindicated).
Common clinical consequences included increased risk of QT-interval prolongation (10.1%), theophylline toxicity (5.1%), antiepileptic toxicity (5.1%), and ceftriaxone calcium precipitation (3.8%).
Significant factors associated with pDDI exposure included infant/toddler age (AOR = 31.961, 95% CI: 1.117–914.528), number of diseases (AOR = 0.255, 95% CI: 0.069–0.939), and polypharmacy (AOR = 0.276, 95% CI: 0.091–0.838).

Cite This Study

Hailesilase et al. (2024) studied this question.

synapsesocial.com/papers/6a1e1b72348274ea529fd798 https://doi.org/10.1186/s12887-024-05128-9

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