Why the study?
Orthostatic hypotension during hemodialysis impacts treatment and quality of life, but a system to monitor autonomic malfunction throughout blood filtration therapy has yet to be discovered.
Does non-invasive monitoring of periflux blood flow decreasing velocity (PDV) using laser-Doppler flowmetry correlate with traditional measures of autonomic dysfunction in stable hemodialysis patients?
Does non-invasive monitoring of periflux blood flow decreasing velocity (PDV) using laser-Doppler flowmetry correlate with traditional measures of autonomic dysfunction in stable hemodialysis patients?
Laser-Doppler flowmetry during the Valsalva manoeuvre provides a non-invasive, reliable measure of autonomic dysfunction in hemodialysis patients that correlates well with traditional markers like heart rate variability and ankle-brachial index.
Answers are grounded in this paper and cite their sources.
May support non-invasive autonomic assessment in hemodialysis; leaves open prospective validation before clinical adoption.
Aim: Although several patients with kidney disease have simultaneous dysfunction of the parasympathetic and sympathetic nervous systems, orthostatic hypotension during a hemodialysis (HD) procedure impacts not only the form of treatment but overall comfort of life for patients with HD. Despite a number of methods that are not invasive and have already been used to assess autonomous functioning, a system for monitoring malfunction throughout filtration of blood therapy which has yet to be discovered. Methods: Regarding the purpose of monitoring the autonomous function of stable 40 regular HD patients and 35 healthy controls, we examined the clinical application of the laser-Doppler blood flow meter (LDF). By detecting the periflux blood flow decreasing velocity (PDV) while combined with the Valsalva manoeuvre, the LDF device which was used for an autonomous test. We also looked at the relationship between PDV and traditional atherosclerosis testing. Results: The baseline PDV (5.30 ± 2.93), comparative to subjects who were in excellent condition (9.65 ± 7.10), was substantially decreased in the HD populace. Furthermore, we discovered a substantial connection between PDV and established parameters like heart rate fluctuation and ankle-brachial blood pressure indexing. Conclusion: Regarding assessing autonomous functioning in hemodialysis patients, evaluation of PDV by LDF is just as effective as the standard approach. The benefit from regular and recurring assessments of autonomous dysfunction is made possible by the device's ease.
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Sapkota et al. (2023) studied this question.
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