Why the study?
RAAS regulates fluid and electrolyte balance and its activation is implicated in CKD causation and progression, motivating an assessment of whether genomic variants within RAAS genes associate with CKD.
Are genomic variants within RAAS genes associated with the development of chronic kidney disease?
Population
114 case-control studies of patients with a defined kidney disease and genotype counts
Comparison
Genomic variants within RAAS genes ACE, ACE2, AGT, AGTR1, AGTR2, and REN vs controls
Design
Systematic review and meta-analysis of observational case-control studies
Authors
Loading...
These RAAS variants may identify lower CKD risk across ethnicities; supports hypothesis generation but should not yet change practice.
Are genomic variants within RAAS genes associated with the development of chronic kidney disease?
Specific genetic variants in the RAAS pathway (ACE insertion, AGT rs699-T, AGTR1 rs5186-A) are associated with a reduced risk of developing chronic kidney disease.
Smyth et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: