Why the study?
Are genetic polymorphisms of the renin-angiotensin system associated with microvascular and macrovascular complications in patients with insulin-dependent diabetes mellitus?
Population
257 Dutch patients with insulin-dependent diabetes mellitus, including 188 with urinary albumin excretion…
Design
Cross-sectional
Authors
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These cross-sectional associations remain hypothesis-generating; prospective studies needed to confirm links to diabetic complications.
Are genetic polymorphisms of the renin-angiotensin system associated with microvascular and macrovascular complications in patients with insulin-dependent diabetes mellitus?
Specific genetic polymorphisms of the renin-angiotensin system, such as AGT-M235T and AT1-A1166C, are associated with increased risks of diabetic complications like elevated UAE, retinopathy, and hypertension in patients with type 1 diabetes.
Ittersum et al. (2000) studied this question.
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