Key result
Genetic polymorphisms in the renin-angiotensin systems, specifically ACE or AT1R, may affect the progression to renal failure in Japanese patients with NIDDM, especially females.
Why the study?
Do genetic polymorphisms in the renin-angiotensin system affect the progression of diabetic nephropathy in Japanese NIDDM patients?
Population
1,152 ethnically homogeneous Japanese patients with non-insulin-dependent diabetes, divided into…
Design
Cross-sectional
Authors
Loading...
Should not yet change practice; hypothesis-generating for sex-specific RAS genotyping in Japanese NIDDM.
Observational (n=1,152)
Yes
Do genetic polymorphisms in the renin-angiotensin system affect the progression of diabetic nephropathy in Japanese NIDDM patients?
Genetic polymorphisms in ACE or AT1R may influence the progression of diabetic nephropathy to renal failure in Japanese patients with NIDDM, particularly in females.
Tomino et al. (1999) conducted an observational in Non-insulin-dependent diabetes (NIDDM) (n=1,152). Genetic polymorphisms in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II receptor (AT1R) was evaluated on Progression of diabetic nephropathy to renal failure. Genetic polymorphisms in the renin-angiotensin systems, specifically ACE or AT1R, may affect the progression to renal failure in Japanese patients with NIDDM, especially females.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: