June 1, 1996Nephrology Dialysis Transplantation
Angiotensin-II type 1 receptor gene polymorphism and diabetic microangiopathy
Key result
Angiotensin-II type 1 receptor A1166-->C polymorphism shows no link to nephropathy or retinopathy in IDDM.
- n=388
Why the study?
Is the A1166-->C polymorphism in the angiotensin-II type 1 receptor gene associated with diabetic nephropathy or proliferative retinopathy in patients with IDDM?
Population
388 Caucasian patients with insulin-dependent diabetes mellitus, including 198 with diabetic nephropathy and…
Comparison
A1166-->C polymorphism in the angiotensin-II… vs Wild-type genotype (AA)
Design
Case-control
Authors
Discussion
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Implication
No association found in this case-control study; leaves open other genetic factors in diabetic nephropathy risk among IDDM patients.
Study Design
Type
Case-Control (n=388)
Structured PICO
Is the A1166-->C polymorphism in the angiotensin-II type 1 receptor gene associated with diabetic nephropathy or proliferative retinopathy in patients with IDDM?
P
Population
388 Caucasian patients with insulin-dependent diabetes mellitus, comparing those with diabetic nephropathy or proliferative retinopathy to those without.
E
Exposure
A1166-->C polymorphism in the angiotensin-II type 1 receptor gene
C
Comparator
Wild-type genotype (AA)
O
Outcome
Presence of diabetic nephropathy or proliferative retinopathy
The A1166-->C polymorphism in the angiotensin-II type 1 receptor gene does not appear to confer genetic susceptibility to diabetic nephropathy or proliferative retinopathy in Caucasian patients with IDDM.
Cite This Study
Tarnow et al. (1996) conducted a case-control in Insulin dependent diabetes mellitus (IDDM) (n=388). A1166-->C polymorphism in the angiotensin-II type 1 receptor gene vs. Normoalbuminuria or no diabetic retinopathy was evaluated on Genotype distribution (AA/AC/CC) and allele frequencies. The A1166-->C polymorphism in the angiotensin-II type 1 receptor gene showed no difference in genotype distribution between IDDM patients with and without diabetic nephropathy or retinopathy.