Why the study?
What are the underlying mechanisms of endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery?
Population
Human submandibular artery tissue
Comparison
Acetylcholine and vasoactive intestinal peptide vs Various inhibitors of endothelial vasodilation…
Design
Preclinical
Authors
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Animal data on submandibular artery vasodilation leave open human applicability; human tissue studies needed before clinical consideration.
What are the underlying mechanisms of endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery?
In the human submandibular artery, ACh and VIP produce endothelium-dependent vasodilation through different mechanisms: ACh relies on nitric oxide and cyclo-oxygenase products, while VIP relies on nitric oxide and endothelium-derived hyperpolarizing factor.
Stojić et al. (2007) studied this question.
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