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June 4, 2008Pharmacology

Effect of Mechanical Stimulation, Substance P and Vasoactive Intestinal Polypeptide on the Electrical and Mechanical Activities of Circular Smooth Muscles from Pig Coronary Arteries Contracted with Acetylcholine: Role of Endothelium

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Why the study?

Do mechanical stimulation, substance P, and VIP induce relaxation in pig coronary arteries, and is this dependent on the endothelium?

Population

Pig coronary arteries (transversal strip of anterior descending branches) precontracted by acetylcholine

Comparison

Mechanical stimulation, substance P, and… vs Intact endothelium versus de-endothelialized…

Design

Preclinical

Authors

JBJean‐Louis BényPBPatrick BruneiHHH Huggel

Discussion

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Overview

Porcine artery data should not guide clinical decisions; leaves open translation to human coronary vasomotor function.

Structured PICO

Do mechanical stimulation, substance P, and VIP induce relaxation in pig coronary arteries, and is this dependent on the endothelium?

P
Population
Pig coronary arteries (transversal strip of anterior descending branches) precontracted by acetylcholine
I
Intervention
Mechanical stimulation, substance P, and vasoactive intestinal polypeptide (VIP)
C
Comparator
Intact endothelium versus de-endothelialized strips
O
Outcome
Smooth muscle relaxation and intracellular membrane potential changessurrogate

Substance P and mechanical stimulation induce endothelium-dependent relaxation and hyperpolarization in pig coronary arteries, whereas VIP causes endothelium-independent relaxation without changing membrane potential.

Cite This Study

Bény et al. (2008) studied this question.

synapsesocial.com/papers/6a81d3bc1325e503433cabfahttps://doi.org/10.1159/000138202
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Smooth muscle dilatation in the human uterine artery induced by substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide and atrial natriuretic peptide: relation to endothelium-derived relaxing substances1992 · 29 citations
  2. 2Effect of vasoactive intestinal peptide and the distribution of receptors in human epicardial coronary arteries1992 · 5 citations
  3. 3Responses of the Human Submandibular Artery to ACh and VIP2007 · 5 citations
  4. 4Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP1987 · 116 citations
  5. 5Mechanisms of Endothelium-Dependent Responses to Vasoactive Agents in Isolated Porcine Coronary Arteries1993 · 23 citations