Why the study?
Atrial oversensing during atrioventricular synchronous pacing with a leadless pacemaker may cause an increase in heart rate with resulting atrioventricular dyssynchrony.
Atrial mechanical oversensing in leadless pacemakers can cause atrioventricular dyssynchrony and subsequent heart failure, highlighting the need for repeated assessment of AV synchrony.
Answers are grounded in this paper and cite their sources.
May prompt AV synchrony checks in symptomatic leadless pacemaker patients; hypothesis-generating case leaves broader risk open.
BACKGROUND: Atrioventricular synchronous pacing with a leadless pacemaker is a therapy used in patients with atrioventricular block. However, atrial oversensing may cause an increase in heart rate, with resulting atrioventricular dyssynchrony. CASE SUMMARY: A 90-year-old woman, who was treated with a leadless pacemaker 2 years earlier for a complete atrioventricular block, developed congestive heart failure. The electrocardiogram revealed an increase in heart rate with atrioventricular dyssynchronous pacing and a decrease in atrioventricular synchronization rate. A manual atrial mechanical test indicated dyssynchronized atrioventricular pacing secondary to atrial mechanical oversensing. DISCUSSION: This case of heart failure exacerbation resulted from 1) the increase in heart rate with atrioventricular dyssynchrony caused by atrial mechanical oversensing and 2) the dyssynchronous pacing resulting from pacing-induced cardiomyopathy. TAKE-HOME MESSAGES: Atrioventricular synchronization can vary with changes in cardiac structure and hemodynamics. It is important to assess atrioventricular synchrony repeatedly in electrocardiograms or rate histograms in the device.
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Ishihara et al. (2025) studied this question.
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